Defective ADP-Induced Platelet Factor 3 Activation in Uremia

Defective ADP-induced platelet factor 3 activation in uremia.

P ATIENTS \VITH UREMIA frequently have both prolonged bleeding times,11#{176} suggesting poor platelet plug formation, and impaired prothrombin consumption,1’2’46’#{176}14 ascribed to defective platelet factor 3 activalion. Considerable evidence points to the presence of a qualitative platelet defect in uremia, since such abnormalities cannot be attributed to the mild thrombocytopenia occasiona...

Platelet Function and Factor VIII in Uremia*

Platelet Activation and Clopidogrel Effects on ADP‐Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3

BACKGROUND Clopidogrel is commonly prescribed to cats with perceived increased risk of thromboembolic events, but little information exists regarding its antiplatelet effects. OBJECTIVE To determine effects of clopidogrel on platelet responsiveness in cats with or without the A31P mutation in the MYBPC3 gene. A secondary aim was to characterize variability in feline platelet responses to clop...

Multistep Reaction in ADP-induced Platelet Aggregation*

The influence of divalent ions and ADP on the induction, relaxation, and stability of the ADP-induced platelet receptor for fibrinogen was investigated. Platelets, isolated by differential sedimentation and gel filtration in calciumand magnesium-free buffer, exhibited a well defined shape change upon ADP stimulation, but aggregation occurred only when calcium or magnesium were added. ‘“I-Fibrin...

Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia.

Poly(ADP-ribose) polymerase 1 (PARP-1) activity is detected in both neuronal and nonneuronal cells in the CNS, and excessive PARP-1 activity is known to be detrimental to tissue because of the cellular energy loss. Accordingly, PARP-1-deficient (PARP-1(-/-)) mice have been shown to be resistant to cerebral ischemia and several forms of inflammation. Recently, PARP-1 in glial cells has been show...